Dutasteride Studies

Dutasteride Research Studies

Published Scientific Studies
Efficacy and safety of a dual inhibitor of 5-alpha-reductase types 1 and 2 (dutasteride) in men with benign prostatic hyperplasia.
Urology 2002 Sep;60(3):434
Managing benign prostatic hyperplasia.
Am Fam Physician 2002 Jul 1;66(1):77-84
Efficacy and safety of a dual inhibitor of 5-alpha-reductase types 1 and 2 (dutasteride) in men with benign prostatic hyperplasia.
World J Urol 2002 Apr;19(6):413-25
Pharmacokinetic parameters and mechanisms of inhibition of rat type 1 and 2 steroid 5alpha-reductases: determinants for different in vivo activities of GI198745 and finasteride in the rat.
Biochem Pharmacol 2001 Oct 1;62(7):933-42
Mass spectral fragmentation reactions of a therapeutic 4-azasteroid and related compounds.
J Am Soc Mass Spectrom 2001 Apr;12(4):385-98
Biochemical and pharmacogenetic dissection of human steroid 5 alpha-reductase type II.
Pharmacogenetics 2000 Jul;10(5):407-13
Dihydrotestosterone and the concept of 5 alpha-reductase inhibition in human benign prostatic hyperplasia.
Eur Urol 2000 Apr;37(4):367-80
Validation of a population pharmacokinetic/pharmacodynamic model for 5 alpha-reductase inhibitors.
Eur J Pharm Sci 1999 Aug;8(4):291-9
The pharmacokinetic modelling of GI198745 (dutasteride), a compound with parallel linear and nonlinear elimination.
Br J Clin Pharmacol 1999 Jan;47(1):53-8
A model for the turnover of dihydrotestosterone in the presence of the irreversible 5 alpha-reductase inhibitors GI198745 and finasteride.
Clin Pharmacol Ther 1998 Dec;64(6):636-47
Discovery and development of GG745, a potent inhibitor of both isozymes of 5 alpha-reductase.
Pharm Biotechnol 1998;11:393-422
Unique Preclinical Characteristics of GG745, A Potent Dual Inhibitor of 5AR
J Pharmacol Exp
 Ther. 1997 Sep;282(3):1496-502.