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Dutasteride Research Studies
 
Publication: J Am Soc Mass Spectrom 2001 Apr;12(4):385-98
Authors: Burinsky DJ, Williams JD, Thornquest AD Jr, Sides SL.
Institution: Pharmaceutical Development Division, GlaxoSmithKline, Research Triangle Park, North Carolina 27709-3398, USA.
 
Mass spectral fragmentation reactions of a therapeutic 4-azasteroid and related compounds.
 

Mass spectra were acquired for a therapeutic 4-azasteroid (dutasteride), and some related compounds, using various ionization conditions (EI, CI, APCI and ESI) in both positive and negative ion modes. The ionization and fragmentation behavior of the compound dutasteride, its precursors and several analogs is reported. Positive atmospheric pressure chemical ionization (APCI+) and positive electrospray ionization (ESI+) produced distinctive collision-induced dissociation (CID) spectra for the respective [MH]+ ions of dutasteride. The spectral differences are attributed to ion populations having either different structures or different internal energy distributions (as a consequence of the method of ionization).

Irrespective of their origin, the protonated molecules undergo interesting fragmentation reactions when collisionally activated. The identity of the major fragmentation products was confirmed by accurate mass measurement. The negative APCI mass spectrum of dutasteride displays extensive dehydrohalogenation, apparently due to the thermal component of the APCI process. Some of the resulting radical anions display remarkable stability toward collisional decomposition. Details of the fragmentation behavior for the negative ion species and their relationship to the positive ion results are discussed.

 
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